Cancer Projects

In the last five years OICR Genomics & Bioinformatics has contributed to a variety of human cancer projects including:

Pancreatic Ductal Adenocarcinoma (PDAC)

PanCuRx: Molecular classification and variant/pathway analyses, combined with well-annotated clinical data to identify prognostic and/or predictive markers, and facilitate the identification of drug targets for molecular therapy.

  • 700 WGS, >271 exomes and >185 transcriptomes
  • WGS of 180 PDAC patients with metastatic disease with timelines to make clinical decisions
related articles

Prostate Cancer

Canadian Prostate Cancer Genome Network (CPC-GENE): Develop biomarkers to stratify intermediate risk prostate cancer patients at high risk of recurrence versus those who can safely be placed under active surveillance protocols.

  • WGS of 265 tumours and ~100 matched references from intermediate risk patients
related articles

Breast Cancer

Establish a diagnostic sequencing approach that provides biomarkers to develop personalized treatment of patients with early invasive breast cancer.

  • Deep targeted sequencing of >1500 FFPE, biopsy samples from patients with early, invasive disease
related articles

Esophageal Adenocarcinoma

Discovery of key biomarkers that can be used to identify progression from parrett's esophagus to invasive esophageal cancer.

  • Deep targeted sequencing of 1000 biopsies
  • 140 exomes
  • 50 transcriptomes
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a. Highly Active Anti-Leukemia Stem Cell Therapy (HALT): International collaboration to develop novel drugs that preferentially target leukemia stem cells in lymphoid and myeloid malignancies and to identify new therapeutic targets.

  • Deep targeted sequencing of 2400 tumours, >100 WGS and >150 exomes

b. European Prospective Investigation into Cancer and Nutrition Study (EPIC): Analyze genetic risk in preleukemic mutation (pLM) carriers who have developed acute myeloid leukemia using one of the largest cohort studies globally.

  • Molecular barcoding combined with deep targeted sequencing of >500 samples
related articles

Colorectal Cancer

Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO): Identify colorectal cancer-associated genetic variants as part of a large collaborative effort of researchers from North America, Australia, and Europe.

  • Deep targeted sequencing of ~4200 tumours/reference pairs
related articles

Impressive Track Record

Read more about our success stories and major research projects.

Interested in Collaborating?

We are eager to collaborate with reserachers who are interested in NGS and analysis services.